| Primary | ||||||||||||
| Date | # | Opp | Score | Inn | Starter | T | W/L | Save | Versus | T | ||
| 4/6/2012 | @ | Tex | L | 8-13 | Sabathia | L | Hanrahan | Lee | L | |||
| 4/7/2012 | @ | Tex | W | 14-1 | Jimenez | R | Jimenez | Niemann | Lincecum | R | ||
| 4/8/2012 | @ | Tex | L | 6-10 | Santana | L | Santana | Garza | R | |||
| 4/9/2012 | @ | Cle | L | 4-6 | Bard | R | Bard | Volquez | R | |||
| 4/10/2012 | @ | Cle | L | 6-7 | Matsuzaka | R | Matsuzaka | Lowe | R | |||
| 4/11/2012 | @ | Cle | W | 5-3 | Sabathia | L | Sabathia | Putz | Haren | R | ||
| 4/13/2012 | Det | W | 2-1 | Jimenez | R | Jimenez | Putz | Lester | L | |||
| 4/14/2012 | Det | L | 4-7 | 16 | Santana | L | Feliciano | Zimmermann | R | |||
| 4/15/2012 | Det | W | 5-2 | Bard | R | Bard | Putz | Vazquez | R | |||
| 4/16/2012 | Bal | W | 6-3 | Matsuzaka | R | Matsuzaka | Pavano | R | ||||
| 4/17/2012 | Bal | L | 4-6 | Sabathia | L | Sabathia | Cahill | R | ||||
| 4/18/2012 | Bal | W | 3-2 | Jimenez | R | Jimenez | Putz | Kennedy | R | |||
| 4/19/2012 | Bal | W | 7-2 | Santana | L | Santana | Hanrahan | Olson | L | |||
| 4/20/2012 | @ | Sea | W | 4-1 | Bard | R | Bard | Putz | Braden | L | ||
| 4/21/2012 | @ | Sea | L | 1-4 | Matsuzaka | R | Matsuzaka | Richard | L | |||
| 4/22/2012 | @ | Sea | W | 2-0 | Sabathia | L | Sabathia | Putz | Verlander | R | ||
| 4/23/2012 | @ | Oak | L | 4-5 | 12 | Jimenez | R | Feliciano | Hanson | R | ||
| 4/24/2012 | @ | Oak | W | 7-4 | Santana | L | Santana | Hanrahan | Marcum | R | ||
| 4/25/2012 | @ | Oak | W | 7-5 | 10 | Bard | R | Putz | Kendrick | R | ||
| 4/26/2012 | Bos | W | 6-1 | Matsuzaka | R | Matsuzaka | Feliciano | Latos | R | |||
| 4/27/2012 | Bos | L | 10-12 | 11 | Sabathia | L | Feliciano | Lackey | R | |||
| 4/28/2012 | Bos | W | 7-1 | Jimenez | R | Jimenez | Niemann | Zito | L | |||
| 4/29/2012 | Bos | W | 6-5 | Santana | L | Santana | Feliciano | Bedard | L | |||
| 5/1/2012 | Cle | W | 6-2 | Bard | R | Bard | Collmenter | R | ||||
| 5/2/2012 | Cle | W | 13-6 | Matsuzaka | R | Matsuzaka | de la Rosa | R | ||||
| 5/3/2012 | Cle | W | 4-0 | Sabathia | L | Sabathia | Volquez | R | ||||
| 5/4/2012 | @ | Det | W | 2-1 | Jimenez | R | Jimenez | Putz | Hernandez | R | ||
| 5/5/2012 | @ | Det | L | 3-6 | Santana | L | Bulger | Zimmermann | R | |||
| 5/6/2012 | @ | Det | W | 8-7 | 12 | Bard | R | Feliciano | Janssen | R | ||
| 5/7/2012 | @ | Cle | L | 3-4 | 13 | Matsuzaka | R | Niemann | de la Rosa | R | ||
| 5/8/2012 | @ | Cle | W | 5-2 | Sabathia | L | Sabathia | Volquez | R | |||
| 5/9/2012 | @ | Cle | L | 1-5 | Jimenez | R | Jimenez | Lowe | R | |||
| 5/11/2012 | KC | W | 6-3 | Santana | L | Santana | Putz | Chapman | L | |||
| 5/12/2012 | KC | L | 1-2 | Bard | R | Bard | Minor | L | ||||
| 5/13/2012 | KC | W | 9-5 | Matsuzaka | R | Matsuzaka | Dempster | R | ||||
| 5/14/2012 | Det | W | 14-5 | Sabathia | L | Sabathia | Niemann | Hernandez | R | |||
| 5/15/2012 | Det | L | 2-4 | 11 | Jimenez | R | Putz | Zimmermann | R | |||
| 5/16/2012 | @ | LAA | W | 5-3 | Santana | L | Feliciano | Bulger | Gallardo | R | ||
| 5/17/2012 | @ | LAA | L | 4-7 | Bard | R | Bard | Carpenter | R | |||
| 5/18/2012 | @ | ChN | L | 0-1 | Matsuzaka | R | Matsuzaka | Feldman | R | |||
| 5/19/2012 | @ | ChN | W | 8-3 | Sabathia | L | Sabathia | Davis | R | |||
| 5/20/2012 | @ | ChN | L | 1-8 | Jimenez | R | Jimenez | Karstens | R | |||
| Other | |||||||||||||
| Cumulative | |||||||||||||
| Date | # | Opp | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# | ||
| 4/6/2012 | @ | Tex | L | 8 | 13 | 0 | 1 | .000 | 0-1 | L1 | 1 | ||
| 4/7/2012 | @ | Tex | W | Reyes | 14 | 1 | 1 | 1 | .500 | 1-1 | W1 | 2 | |
| 4/8/2012 | @ | Tex | L | 6 | 10 | 1 | 2 | .333 | 1-2 | L1 | 3 | ||
| 4/9/2012 | @ | Cle | L | 4 | 6 | 1 | 3 | .250 | 1-3 | L2 | 4 | ||
| 4/10/2012 | @ | Cle | L | 6 | 7 | 1 | 4 | .200 | 1-4 | L3 | 5 | ||
| 4/11/2012 | @ | Cle | W | Gonzalez | 5 | 3 | 2 | 4 | .333 | 2-4 | W1 | 6 | |
| 4/13/2012 | Det | W | Reyes | 2 | 1 | 3 | 4 | .429 | 3-4 | W2 | 7 | ||
| 4/14/2012 | Det | L | 4 | 7 | 3 | 5 | .375 | 3-5 | L1 | 8 | |||
| 4/15/2012 | Det | W | Gonzalez | 5 | 2 | 4 | 5 | .444 | 4-5 | W1 | 9 | ||
| 4/16/2012 | Bal | W | Gonzalez | 6 | 3 | 5 | 5 | .500 | 5-5 | W2 | 10 | ||
| 4/17/2012 | Bal | L | 4 | 6 | 5 | 6 | .455 | 5-5 | L1 | 11 | |||
| 4/18/2012 | Bal | W | Reyes | 3 | 2 | 6 | 6 | .500 | 5-5 | W1 | 12 | ||
| 4/19/2012 | Bal | W | Gonzalez | 7 | 2 | 7 | 6 | .538 | 6-4 | W2 | 13 | ||
| 4/20/2012 | @ | Sea | W | Encarnacion | 4 | 1 | 8 | 6 | .571 | 7-3 | W3 | 14 | |
| 4/21/2012 | @ | Sea | L | 1 | 4 | 8 | 7 | .533 | 7-3 | L1 | 15 | ||
| 4/22/2012 | @ | Sea | W | Brown | 2 | 0 | 9 | 7 | .563 | 7-3 | W1 | 16 | |
| 4/23/2012 | @ | Oak | L | 4 | 5 | 9 | 8 | .529 | 6-4 | L1 | 17 | ||
| 4/24/2012 | @ | Oak | W | Brown | 7 | 4 | 10 | 8 | .556 | 7-3 | W1 | 18 | |
| 4/25/2012 | @ | Oak | W | Sizemore | 7 | 5 | 11 | 8 | .579 | 7-3 | W2 | 19 | |
| 4/26/2012 | Bos | W | Sizemore | 6 | 1 | 12 | 8 | .600 | 7-3 | W3 | 20 | ||
| 4/27/2012 | Bos | L | 10 | 12 | 12 | 9 | .571 | 7-3 | L1 | 21 | |||
| 4/28/2012 | Bos | W | Brown | 7 | 1 | 13 | 9 | .591 | 7-3 | W1 | 22 | ||
| 4/29/2012 | Bos | W | Sizemore | 6 | 5 | 14 | 9 | .609 | 7-3 | W2 | 23 | ||
| 5/1/2012 | Cle | W | Encarnacion | 6 | 2 | 15 | 9 | .625 | 7-3 | W3 | 24 | ||
| 5/2/2012 | Cle | W | Brown | 13 | 6 | 16 | 9 | .640 | 8-2 | W4 | 25 | ||
| 5/3/2012 | Cle | W | Johnson | 4 | 0 | 17 | 9 | .654 | 8-2 | W5 | 26 | ||
| 5/4/2012 | @ | Det | W | Encarnacion | 2 | 1 | 18 | 9 | .667 | 9-1 | W6 | 27 | |
| 5/5/2012 | @ | Det | L | 3 | 6 | 18 | 10 | .643 | 8-2 | L1 | 28 | ||
| 5/6/2012 | @ | Det | W | Johnson | 8 | 7 | 19 | 10 | .655 | 8-2 | W1 | 29 | |
| 5/7/2012 | @ | Cle | L | 3 | 4 | 19 | 11 | .633 | 7-3 | L1 | 30 | ||
| 5/8/2012 | @ | Cle | W | Reyes | 5 | 2 | 20 | 11 | .645 | 8-2 | W1 | 31 | |
| 5/9/2012 | @ | Cle | L | 1 | 5 | 20 | 12 | .625 | 7-3 | L1 | 32 | ||
| 5/11/2012 | KC | W | Gonzalez | 6 | 3 | 21 | 12 | .636 | 7-3 | W1 | 33 | ||
| 5/12/2012 | KC | L | 1 | 2 | 21 | 13 | .618 | 6-4 | L1 | 34 | |||
| 5/13/2012 | KC | W | Gonzalez | 9 | 5 | 22 | 13 | .629 | 6-4 | W1 | 35 | ||
| 5/14/2012 | Det | W | Napoli | 14 | 5 | 23 | 13 | .639 | 6-4 | W2 | 36 | ||
| 5/15/2012 | Det | L | 2 | 4 | 23 | 14 | .622 | 5-5 | L1 | 37 | |||
| 5/16/2012 | @ | LAA | W | Quentin | 5 | 3 | 24 | 14 | .632 | 6-4 | W1 | 38 | |
| 5/17/2012 | @ | LAA | L | 4 | 7 | 24 | 15 | .615 | 5-5 | L1 | 39 | ||
| 5/18/2012 | @ | ChN | L | 0 | 1 | 24 | 16 | .600 | 5-5 | L2 | 40 | ||
| 5/19/2012 | @ | ChN | W | Sizemore | 8 | 3 | 25 | 16 | .610 | 5-5 | W1 | 41 | |
| 5/20/2012 | @ | ChN | L | 1 | 8 | 25 | 17 | .595 | 5-5 | L1 | 42 | ||